A functionalized gold nanoparticles-assisted universal carrier for antisense DNA.
نویسندگان
چکیده
In this study, single-stranded DNA functionalized gold nanoparticles (AuNP GDS) were proved to be efficient gene delivery systems for oligo antisense DNAs specific to any gene of interest without affecting normal cell physiology.
منابع مشابه
Synthesis and Functionalization of Gold Nanoparticles by Using of Poly Functional Amino Acids
Synthesis and characterization of two functionalized gold nanoparticles by using of two poly functional amino acids (L-Arginine and L-Aspartic acid) are reported. The gold nanoparticles were reduced by sodium citrate and functionalized with L-Arginine at the pH of 7 and 11 and L-Aspartic acid at the pH of 7. Transmission electron microscopy, UV-Vis spectroscopy, dynamic light scattering, zeta p...
متن کاملWater-based Double Layer Functionalized Iron Oxide Nanoparticles for Enhanced Gene Delivery Applications
Iron oxide nanoparticles (magnetite (Fe3O4), hematite (Fe2O3)) have been received increasing attention in drug and gene delivery. In this work, water-base double layer functionalized iron oxide nanoparticles (DL-IONPs) were designed and prepared of a biodegradable, biocompatible carrier by co-precipitation method with high DNA loading capacity due to self-assembly of a second organic layer. The...
متن کاملAssembly of DNA-functionalized gold nanoparticles on electrospun nanofibers as a fluorescent sensor for nucleic acids.
A facile approach was developed to assemble DNA-functionalized gold nanoparticles on the electrospun nanofibers. This novel nanocomposite was successfully applied to constructing a highly sensitive and selective fluorescent sensor for nucleic acids.
متن کاملPreparation of gold nanoparticle-DNA conjugates.
This unit describes the preparation of conjugates between nanometer-scale gold particles and synthetic oligonucleotides. Oligonucleotide-functionalized gold nanoparticles are finding increased use in both the construction of complex, tailored nanostructures and the optimization of DNA sequence analysis. The protocols in this unit outline the synthesis, purification, and characterization of nano...
متن کاملSelf-aggregation of oligonucleotide-functionalized gold nanoparticles and its applications for highly sensitive detection of DNA.
A new self-aggregation phenomenon of single strand DNA-modified gold nanoparticles has been demonstrated and applied to highly sensitive DNA detection.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Chemical communications
دوره 46 23 شماره
صفحات -
تاریخ انتشار 2010